Lecture: M 6:00-8:30 p.m. Instructor: Dr. Rob Pfaff
Science 301 Office Hours: M 10:00 - 10:50
WF 11:00 - 11:50
(and by appointment)
Office: S 304A
Phone: 866-6380
Med Chem is a predominantly practical course intended for upper division chemistry and biology students. Familiarity with some organic chemistry and cell biology is expected.
There is one required text for the course: Williams and Lemke, Foye’s Principles of Medicinal Chemistry, 6th Edition, Lippincott Williams and Wilkins, 2007.
LECTURE COVERAGE
The following material will be covered on or about the dates indicated. If warranted, this schedule may be revised as the semester progresses.
|
Week |
Beginning Date |
Material in Williams and Lemke |
|
1 |
8/24 |
Introduction, Chapters 1, 2 |
|
2 |
8/31 |
Chapters 2, 3 |
|
3 |
9/7 |
No Class – Labor Day |
|
4 |
9/14 |
Chapters 4, 7, 10 |
|
5 |
9/21 |
Chapters 10, 11 |
|
6 |
9/28 |
Chapters 12, 13 Exam 1 due 6:00 p.m. |
|
7 |
10/5 |
Chapters 14, 15 |
|
8 |
10/12 |
Chapters 19, 22, 23 |
|
9 |
10/19 |
Chapters 23-25 |
|
10 |
10/26 |
Chapters 25, 26, 28 |
|
11 |
11/2 |
Chapters 28, 29 Exam 2 due 6:00 p.m. |
|
12 |
11/9 |
Chapters 29, 33, 38 |
|
13 |
11/16 |
Chapters 38, 42 Research Papers due Wednesday at noon |
|
|
11/23 |
No Classes – Thanksgiving week |
|
14 |
11/30 |
Chapters 42, 43, Presentations |
|
15 |
12/7 |
Presentations |
Cumulative Final Exam due Monday, December 14, 2009, at 6:00 p.m.
EXAMS AND GRADING
The grading in this course will be derived from two 100 point take-home exams, a 100 point in-class presentation, a 100 point research paper, and a 200 point cumulative final exam. Your total points will be converted to a percentage of the 600 points available and letter grades will be assigned on that basis. Students are expected to take all exams at the scheduled times. If a conflict should arise which prevents taking an exam at the scheduled time, I may, at my discretion, grant a make up. Requests for make-ups MUST be made before the scheduled exam time (even a phone message may suffice). Requests made after the scheduled time will not be considered. There will be NO exceptions. You are responsible for topics covered in the text, even if they are not covered in class. You are also responsible for topics covered in class, even if they are not covered in the text.
The presentations are actually fairly simple. Each student will choose a chapter not covered in the course and give a summary presentation on it. Essentially, the student will teach the class for a day. Chapter choices will be made early in the semester.
The research paper is a traditional one. Each student will choose a drug, drug class, or disease to do a review of. Since this is a medicinal chemistry class, a disease paper must concentrate on drug intervention approaches. The paper must be a minimum of 10 pages of text, plus footnotes (gathered at the end) and a title page. References should concentrate on the primary (journal) literature, not websites. The paper should be written in the format of a chemistry journal article; consult the most recent Journal of Medicinal Chemistry in the Chem Reading Room (or online from the Library collection) for examples. Although articles are often printed in 2-column format, your paper should be 1-column. Note that the structures of drug molecules discussed must be included in the paper. This paper will be submitted to turnitin.com. Our course ID is xxxxxxx and the enrollment password is yyyyy.
On all written work, proper grammar and sentence structure are expected and points will be lost for bad grammar and sentence structure. Obviously, this is not an English class but good communications skills are essential in chemistry. You will also be required to use the American spellings of chemicals.
In addition, it is my policy NOT to approve dropping the course after the College’s official drop date.
In view of the H1N1 virus, students will be not penalized if they become ill during the semester. Stay in and seek medical attention if you experience any flu-related symptoms, rather than attend class.
If you are a student with a disability, kindly meet with me immediately to discuss the accommodations you will need during class activities, examinations, and out of class assignments in order to participate fully and demonstrate your abilities.
The anticipated grade cut-offs are below. They may not be the final cut-offs but they will give you an idea of your status. In the past, cut-offs have always stayed the same or have been dropped slightly. Therefore, these cut-offs can be regarded as giving your minimum grade.
A 93%
A- 90%
B+ 87%
B 83%
B- 80%
C+ 77%
C 68%
C- 65%
D+ 61%
D 50%